The Caenorhabditis protein annotation program focuses on the manual annotation of C. elegans and C. briggsae proteins.
UniProtKB works closely both with the worm research community and with WormBase, the database of the biology and genome of C. elegans and related nematode species, to ensure that UniProtKB data remains complete and up-to-date. The focus in the nematode research community is on the characterisation of C. elegans proteins. This means that there is more literature available for this species which explains the more detailed annotation available in UniProtKB. The majority of C. briggsae proteins are uncharacterised and the annotation in UniProtKB/Swiss-Prot for these uncharacterised proteins is propagated from the C. elegans orthologs.
- All manually reviewed C. elegans entries can be found here (statistics)
- All manually reviewed C. briggsae entries can be found here (statistics)
The nematode worm, Caenorhabditis elegans, is a free-living, transparent roundworm, approximately 1mm in length, which lives in temperate soil environments. It is used extensively as a model organism due to its small size, short life cycle, its transparent body which allows the observation of various processes in the intact organism and the ease with which specific genes can be disrupted, giving an insight into gene and protein function. The developmental origin of each cell in the adult has been precisely mapped – facilitating developmental and cell fate studies. The process of RNA interference was discovered in C.elegans by Fire and Mellor, who subsequently received the Nobel prize for their efforts. It was the first multicellular organism to have its genome sequenced. The sequence was published in 1998, providing an impetus for gene and protein prediction and annotation. In 2003, the genome sequence of the related nematode Caenorhabditis briggsae was also determined, facilitating comparative genomics studies between these two organisms. Three more Caenorhabditis species, C. brennari, C. japonica and C. remanei, are currently being sequenced. As advances in sequencing technology make genome sequencing faster and cheaper, the genomes of additional nematode species are expected.