UniProt release 9.2
Published November 28, 2006
All known human G protein-coupled receptor proteins in UniProtKB/Swiss-Prot
The Human Proteome Initiative (HPI) aims to annotate all known human protein sequences, as well as their mammalian orthologs. The G protein-coupled receptor proteins (GPCRs), also known as seven transmembrane receptors (7TM receptors) form one of the largest proteins family in mammalian genomes. These proteins are involved in all types of stimulus-response pathways, from intercellular communication to physiological senses, including taste, smell, and vision (opsins receptors). Many diseases are linked to GPCRs and half of the drug products by the pharmaceutical industry are targeted against GPCRs. A special emphasis has been given to this family in the HPI project.
In the current release, all known and potential human G protein-coupled receptor protein are annotated and integrated in UniProtKB/Swiss-Prot. 775 human GPCRs are now available in our knowledgebase. About half of all GPCRs are presumed to be involved in the sense of smell. For the remaining half, the active ligand has been documented when available, but about 20% of human GPCRs are still orphans. Most of mouse and rat orthologs have been annotated.
All G protein-coupled receptor proteins annotated in UniProtKB/Swiss-Prot are classified by family and listed in the file 7tmrlist.txt.
Cross-references to Gene3D
Cross-references have been added to the Gene3D Structural and Functional Annotation of Protein Families database. Gene3D database provides a combined structural, functional and evolutionary view of the protein world. It is focussed on providing structural annotation for protein sequences without structural representatives -- including the complete proteomes of over 240 different species. The protein sequences have also been clustered into whole-chain families so as to aid functional prediction. The structural annotation is generated using HMM models based on the CATH domain families; CATH is a repository for manually deduced protein domains.
The Gene3D is available at http://cathwww.biochem.ucl.ac.uk:8080/Gene3D/.
The format of the explicit links in the flat file is:
|Resource identifier||Gene3D identifier.|
|Optional information 1||Gene3D entry name|
Changes concerning keywords