UniProt release 5.5
Published July 19, 2005
Headlines
Orangutan, the most represented non-human primate in UniProtKB/Swiss-Prot
With more than 500 entries, Pongo pygmaeus (Orangutan) is now the most represented non-human primate. Most of these entries are built around sequence data generated by a cDNA sequencing project launched by the German cDNA Consortium in 2003. Almost 4'000 entries submitted by the consortium are still in UniProtKB/TrEMBL. It should be noted however that some of these sequences are fragments and are thus not a priority for UniProtKB/Swiss-Prot annotation. We plan to manually annotate as many Orangutan entries as possible, starting with sequences orthologous to human ones already described in Swiss-Prot.
There are currently almost 15'500 primate entries in Swiss-Prot, 82% of which describe human proteins.
UniProtKB News
Obsolete file uniprot_trembl_varsplic.fasta.gz
All UniProtKB/TrEMBL entries with annotated alternative splicing events (KW Alternative splicing) have been moved to UniProtKB/Swiss-Prot. Thus the file uniprot_trembl_varsplic.fasta.gz became obsolete and has been removed from the ftp site.
Please note that UniProtKB/TrEMBL still includes splice isoforms, but each in an individual entry and not merged into one single entry.
Cross-references to Genew
The format of the UniProtKB cross-reference to the Human Gene Nomenclature Database Genew has changed: The term Genew has been replaced by HGNC, which stands for HUGO Gene Nomenclature Committee.
Example:
DR Genew; HGNC:12849; YWHAB.
has changed to
DR HGNC; HGNC:12849; YWHAB.
Changes concerning keywords
New keyword:
Deleted keyword:
- Calcium-binding
Changes concerning the controlled vocabulary for PTMs
New terms for the feature key 'CROSSLNK':
- Cyclopeptide (Arg-Cys) (interchain with C-...)
- Cyclopeptide (Cys-Arg) (interchain with R-...)
New term for the feature key 'MOD_RES':
- N6-carboxylysine