UniProt release 1.10

UniProtKB news

New comment line (CC) topic: TOXIC DOSE

We have introduced a new comment (CC) line topic: TOXIC DOSE. This topic is used to store information on the poisoning potential (acute toxicity) of a toxin.

Generally this topic holds information on the LD(50) and PD(50). LD stands for "Lethal Dose". LD(50) is the amount of a toxin, given all at once, which causes the death of 50% (one half) of a group of test animals.

PD(50) stands for "Paralytic dose". It is the amount of a toxin, which causes the paralysis of 50% of a group of test animals.

Examples:

CC   -!- TOXIC DOSE: PD(50) is 1.72 mg/kg by injection in blowfly larvae.

CC   -!- TOXIC DOSE: LD(50) is 0.015 mg/kg by intravenous injection for
CC       sarafotoxin-A and sarafotoxin-B, and 0.3 mg/kg for sarafotoxin-C.

Changes concerning keywords

New keywords:

• Primary microcephaly
• Protein phosphatase

Changes concerning the controlled vocabulary for PTMs

We are continuously overhauling the annotation of post-translational modifications (PTMs). For the feature key MOD_RES, the new initially introduced controlled vocabularies for PTMs are:

• Acetylation: All entries with annotated acetylation sites have the keyword Acetylation.

  N-acetylalanine
  N-acetylaspartate
  N-acetylcysteine
  N-acetylglutamate
  N-acetylglycine
  N-acetylmethionine
  N-acetylproline
  N-acetylserine
  N-acetylthreonine
  N-acetyltyrosine
  N-acetylvaline
  N2-acetylarginine
  N6-acetyllysine
  

• Amidation: All entries with annotated amidation sites have the keyword Amidation.

  Alanine amide
  Arginine amide
  Aspartic acid 1-amide
  Asparagine amide
  Cysteine amide
  Glutamic acid 1-amide
  Glutamine amide
  Glycine amide
  Histidine amide
  Isoleucine amide
  Leucine amide
  Lysine amide
  Methionine amide
  Phenylalanine amide
  Proline amide
  Serine amide
  Threonine amide
  Tryptophan amide
  Tyrosine amide
  Valine amide 
  

• Isomerization: All entries with annotated isomerization sites have the keyword D-amino acid.

  D-alanine (Ala)
  D-alanine (Ser)
  D-asparagine
  D-allo-isoleucine
  D-leucine
  D-methionine
  D-phenylalanine
  D-serine
  D-tryptophan 
  

• Other new controlled vocabularies for PTMs that are annotated with the feature key MOD_RES:

   2',4',5'-topaquinone (keyword: TPQ)
  3-phenyllactic acid
  N6-1-carboxyethyl lysine
  2,3-didehydroalanine (Ser)
  2,3-didehydrobutyrine
  (Z)-2,3-didehydrotyrosine