UniProt release 1.10
Published May 24, 2004
New comment line (CC) topic: TOXIC DOSE
We have introduced a new comment (CC) line topic: TOXIC DOSE. This topic is used to store information on the poisoning potential (acute toxicity) of a toxin.
Generally this topic holds information on the LD(50) and PD(50). LD stands for "Lethal Dose". LD(50) is the amount of a toxin, given all at once, which causes the death of 50% (one half) of a group of test animals.
PD(50) stands for "Paralytic dose". It is the amount of a toxin, which causes the paralysis of 50% of a group of test animals.
CC -!- TOXIC DOSE: PD(50) is 1.72 mg/kg by injection in blowfly larvae.
CC -!- TOXIC DOSE: LD(50) is 0.015 mg/kg by intravenous injection for CC sarafotoxin-A and sarafotoxin-B, and 0.3 mg/kg for sarafotoxin-C.
Changes concerning keywords
Changes concerning the controlled vocabulary for PTMs
We are continuously overhauling the annotation of post-translational modifications (PTMs). For the feature key MOD_RES, the new initially introduced controlled vocabularies for PTMs are:
Acetylation: All entries with annotated acetylation sites have the keyword Acetylation.
N-acetylalanine N-acetylaspartate N-acetylcysteine N-acetylglutamate N-acetylglycine N-acetylmethionine N-acetylproline N-acetylserine N-acetylthreonine N-acetyltyrosine N-acetylvaline N2-acetylarginine N6-acetyllysine
Amidation: All entries with annotated amidation sites have the keyword Amidation.
Alanine amide Arginine amide Aspartic acid 1-amide Asparagine amide Cysteine amide Glutamic acid 1-amide Glutamine amide Glycine amide Histidine amide Isoleucine amide Leucine amide Lysine amide Methionine amide Phenylalanine amide Proline amide Serine amide Threonine amide Tryptophan amide Tyrosine amide Valine amide
Isomerization: All entries with annotated isomerization sites have the keyword D-amino acid.
D-alanine (Ala) D-alanine (Ser) D-asparagine D-allo-isoleucine D-leucine D-methionine D-phenylalanine D-serine D-tryptophan
Other new controlled vocabularies for PTMs that are annotated with the feature key MOD_RES:
2',4',5'-topaquinone (keyword: TPQ) 3-phenyllactic acid N6-1-carboxyethyl lysine 2,3-didehydroalanine (Ser) 2,3-didehydrobutyrine (Z)-2,3-didehydrotyrosine