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UniProt release 1.10

Published May 24, 2004

UniProtKB news

New comment line (CC) topic: TOXIC DOSE

We have introduced a new comment (CC) line topic: TOXIC DOSE. This topic is used to store information on the poisoning potential (acute toxicity) of a toxin.

Generally this topic holds information on the LD(50) and PD(50). LD stands for "Lethal Dose". LD(50) is the amount of a toxin, given all at once, which causes the death of 50% (one half) of a group of test animals.

PD(50) stands for "Paralytic dose". It is the amount of a toxin, which causes the paralysis of 50% of a group of test animals.

Examples:

CC   -!- TOXIC DOSE: PD(50) is 1.72 mg/kg by injection in blowfly larvae.
CC   -!- TOXIC DOSE: LD(50) is 0.015 mg/kg by intravenous injection for
CC       sarafotoxin-A and sarafotoxin-B, and 0.3 mg/kg for sarafotoxin-C.

Changes concerning keywords

New keywords:


Changes concerning the controlled vocabulary for PTMs

We are continuously overhauling the annotation of post-translational modifications (PTMs). For the feature key MOD_RES, the new initially introduced controlled vocabularies for PTMs are:

  • Acetylation: All entries with annotated acetylation sites have the keyword Acetylation.

    N-acetylalanine
    N-acetylaspartate
    N-acetylcysteine
    N-acetylglutamate
    N-acetylglycine
    N-acetylmethionine
    N-acetylproline
    N-acetylserine
    N-acetylthreonine
    N-acetyltyrosine
    N-acetylvaline
    N2-acetylarginine
    N6-acetyllysine
    
  • Amidation: All entries with annotated amidation sites have the keyword Amidation.

    Alanine amide
    Arginine amide
    Aspartic acid 1-amide
    Asparagine amide
    Cysteine amide
    Glutamic acid 1-amide
    Glutamine amide
    Glycine amide
    Histidine amide
    Isoleucine amide
    Leucine amide
    Lysine amide
    Methionine amide
    Phenylalanine amide
    Proline amide
    Serine amide
    Threonine amide
    Tryptophan amide
    Tyrosine amide
    Valine amide 
    
  • Isomerization: All entries with annotated isomerization sites have the keyword D-amino acid.

    D-alanine (Ala)
    D-alanine (Ser)
    D-asparagine
    D-allo-isoleucine
    D-leucine
    D-methionine
    D-phenylalanine
    D-serine
    D-tryptophan 
    
  • Other new controlled vocabularies for PTMs that are annotated with the feature key MOD_RES:

     2',4',5'-topaquinone (keyword: TPQ)
    3-phenyllactic acid
    N6-1-carboxyethyl lysine
    2,3-didehydroalanine (Ser)
    2,3-didehydrobutyrine
    (Z)-2,3-didehydrotyrosine