Last modified September 9, 2013
This subsection of the ‘General annotation (Comments)’ section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the ‘Function’ subsection).
1. Quaternary structure
The composition of the quaternary structure is explicitly described. Chains or subunits are cited either specifically with gene names or in a generic way if there are a number of interchangeable participants.
Examples: P83448, P57530, P32323
2. Protein-protein interactions
We describe protein-protein interactions and generally use the primary gene name to cite the interacting protein. If no gene name is available, the appropriate protein name is used. If the gene name is not frequently used in scientific literature, we further specify it by appending through a slash ”/” an additional gene synonym or a protein name or synonym.
Examples: Q4KLM5, Q9BXJ7
If appropriate, we provide additional information resulting from a given interaction, such as prerequisite or resulting post-translational modification(s), isoform specificity or involved domains.
Examples: Q9Y3D6, O60239
3. Host-pathogen protein-protein interactions
Related keyword: Host-virus interaction
4. Protein-complex interactions
Interactions can be propagated ‘By similarity’ to closely related species.