Keywords
Last modified December 9, 2008
This subsection of the ‘Ontologies’ section lists selected keyword(s), derived from a thesaurus of controlled vocabulary with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitates the search of proteins of interest.
- Biological process
- Cellular component
- Coding sequence diversity
- Developmental stage
- Disease
- Domain
- Ligand
- Molecular function
- Post-translation modification
- Technical term
An entry often contains several keywords. Inside a category, the keywords are stored by alphabetical order.
Example: P05067
Keywords can be used to retrieve subsets of protein entries or to generate indexes of entries based on functional, structural, or other categories.
Keywords in UniProtKB/TrEMBL
UniProtKB/TrEMBL makes use of the same list of keywords as UniProtKB/Swiss-Prot but, because most keywords in an entry are added in the manual annotation process, UniProtKB/TrEMBL entries generally contain fewer keywords than UniProtKB/Swiss-Prot entries. The main sources of UniProtKB/TrEMBL keywords are:- The underlying nucleotide entry. The nucleotide databases (e.g. EMBL) contain keywords that are transferred to the corresponding UniProtKB/TrEMBL entry provided they are also present in the UniProtKB keyword list.
- The program which creates UniProtKB/TrEMBL entries. This adds keywords based on information in the underlying nucleotide entry. For example, if a nucleotide entry contains the word “kinase” in the description field, the program will add the keyword “Kinase” to the corresponding UniProtKB/TrEMBL entry.
- Automatic annotation.
