General annotation (Comments)
Last modified February 17, 2011
This section provides any useful information about the protein, mostly biological knowledge.
The information is filed in different subsections. The current subsections and their content are listed below:
| Subsection | Content |
| Function | General function(s) of a protein |
| Catalytic activity | Reaction(s) catalyzed by an enzyme |
| Cofactor | Non-protein substance required for enzyme activity |
| Enzyme regulation | Enzyme regulatory mechanism |
| Biophysicochemical properties | Biophysical and physicochemical properties |
| Subunit structure | Interaction with other protein(s) |
| Pathway | Associated metabolic pathways |
| Subcellular location | Subcellular location of the mature protein |
| Tissue specificity | Expression of the gene product in different tissues |
| Developmental stage | Expression of the gene product according to the cell stage and/or tissue or organism development |
| Induction | Effects of environmental factors on gene expression |
| Domain | Relevant information on protein domain(s) |
| Post-translational modification | Post-translational modifications |
| RNA editing | Amino acid variation(s) due to RNA editing |
| Mass spectrometry | Information derived from mass spectrometry experiments |
| Polymorphism | Description of polymorphism(s) |
| Involvement in disease | Disease(s) associated with protein defect(s) |
| Disruption phenotype | Description of the effects caused by the disruption of a protein-encoding gene |
| Allergenic properties | Information relevant to allergenic proteins |
| Toxic dose | Lethal, paralytic, effect dose or lethal concentration of a toxin |
| Biotechnological use | Use in a biotechnological process |
| Pharmaceutical use | Use of as a pharmaceutical drug |
| Miscellaneous | Any relevant information that doesn’t fit in any other defined sections |
| Sequence similarities | Description of the sequence similaritie(s) with other proteins and family attribution |
| Caution | Warning about possible errors and/or grounds for confusion |
| Sequence caution | Warning about possible errors related to the protein sequence |