Last modified February 17, 2011
This subsection of the ‘General annotation (Comments)’ section describes the effects caused by the disruption of the gene coding for the protein described in the entry.
Note that we only describe effects caused by the complete absence of a gene, and thus of a protein, in vivo (null mutants caused by random or target deletions, insertions of a transposable element, etc.).
To avoid description of phenotypes due to partial or dominant negative mutants, missense mutations are not described in this subsection, but in the ‘Sequence annotation (Features)’ section, ‘Mutagenesis’ subsection.
Defects caused by transient inactivation, for instance by RNA interference or blockade by antibodies, are not described due to the difficulty of the interpretation of the results.