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91 results in User manual

› Restrict list of documents to category: alternative_products, binary_interactions, cross_references, entry_information, general_annotation, names_origin, ontologies, protein_attributes, references, sequence_annotation, sequences, web_resources

Alternative products

Description of the different proteins generated from the same gene

Binary interactions

Information relevant to binary protein-protein interactions


Cross-references that point to data collections other than UniProtKB

Entry information

Entry status Indicates if the entry has been manually reviewed (UniProtKB/Swiss-Prot) or not (UniProtKB/TrEMBL)
Entry name Mnemonic identifier for a UniProtKB entry
Entry history Dates of creation and modification and version information
Accession Provides a stable way of identifying UniProtKB entries

General annotation (Comments)

Position-independent annotation
Toxic dose Lethal, paralytic, or effect dose, or lethal concentration of a toxin
Tissue specificity Description of the expression of a gene in different tissues
Subunit structure Description of the quaternary structure of a protein
Subcellular location Description of the subcellular location of the mature protein
Sequence similarities Description of the sequence similaritie(s) with other proteins
Sequence caution Warning about possible errors related to the protein sequence
RNA editing Description of amino acid change(s) due to RNA editing
Post-translational modification Description of post-translational modifications
Polymorphism Description of polymorphism(s)
Pharmaceutical use Description of the use of a protein as a pharmaceutical drug
Pathway Description of associated metabolic pathways
Non-experimental qualifiers Non-experimental qualifiers indicate that the information given is not based on experimental findings.
Miscellaneous Any relevant information that doesn't fit in any other defined sections
Mass spectrometry Information derived from mass spectrometry experiments
Involvement in disease Description of the disease(s) associated with the deficiency of a protein
Induction Description of the effects of environmental factors on the gene expression
Function General description of the function(s) of a protein
Enzyme regulation Description of an enzyme regulatory mechanism
Domain Description of the domain(s) present in a protein
Disruption phenotype Description of the effects caused by the disruption of a protein-encoding gene.
Developmental stage Description of how the expression of a gene varies according to the stage of cell, tissue or organism development
Cofactor Description of non-protein substance required by an enzyme to be active
Caution Warning about possible errors and/or grounds for confusion
Catalytic activity Description of the reaction(s) catalyzed by an enzyme
Biotechnological use Description of the use of a specific protein in a biotechnological process
Biophysicochemical properties Description of biophysical and physicochemical properties
Allergenic properties Information relevant to allergenic proteins

Names origin

Virus host The species that can be infected by a specific virus
Taxonomic lineage Taxonomic classification of the source organism
Taxonomic identifier NCBI unique identifier for the source organism
Protein names Name and synonyms of the protein
Organism Name of the source organism
Gene names Name(s) of the gene(s) that code for the protein
Encoded on Organelle or plasmid gene source


Keywords List of controlled vocabulary which summarises the content of an entry
Gene Ontology (GO) Selection of Gene Ontology (GO) terms

Protein attributes

Sequence status Indicates if the protein sequence is complete or not
Sequence processing Indicates if the mature form of a protein is derived by processing of a precursor
Sequence length Sequence length
Protein existence Level of evidence that supports the existence of the protein concerned


Literature citations

Sequence annotation (Features)

Position-dependent annotation
Zinc finger Denotes the position(s) and type(s) of zinc fingers within the protein
Natural variant Description of a natural variant of the protein
Alternative sequence Amino acid change(s) producing alternate protein isoforms
Sequence uncertainty Regions of uncertainty in the sequence
Turn Turns within the experimentally determined protein structure
Transmembrane Extent of a membrane-spanning region
Transit peptide Extent of a transit peptide for organelle targeting
Topological domain Location of non-membrane regions of membrane-spanning proteins
Beta strand Beta strand regions within the experimentally determined protein structure
Site Any interesting single amino acid site on the sequence
Signal Sequence targeting proteins to the secretory pathway or periplasmic space
Repeat Denotes the positions of repeated sequence motifs or repeated domains
Region Region of interest in the sequence
Propeptide Part of a protein that is cleaved during maturation or activation
Peptide Extent of an active peptide in the mature protein
Nucleotide binding Nucleotide phosphate binding region
Non-terminal residue The sequence is incomplete. Indicate that a residue is not the terminal residue of the complete protein.
Non-standard residue Occurence of non-standard amino acids (selenocysteine and pyrrolysine) in the protein sequence
Non-experimental qualifiers Non-experimental qualifiers indicate that the information given is not based on experimental findings.
Non-adjacent residues Indicates that two residues in a sequence are not consecutive
Mutagenesis Site which has been experimentally altered by mutagenesis
Motif Short (up to 20 amino acids) sequence motif of biological interest
Modified residue Modified residues excluding lipids, glycans and protein crosslinks
Metal binding Binding site for a metal ion
Lipidation Covalently attached lipid group(s)
Intramembrane Extent of a region located in a membrane without crossing it
Initiator methionine Cleaved initiator methionine
Helix Helical regions within the experimentally determined protein structure
Domain Denotes the position and type of each modular protein domain
DNA binding Denotes the position and type of a DNA-binding domain
Disulfide bond Cysteine residues participating in disulfide bonds
Cross-link Residues participating in covalent linkage(s) between proteins
Sequence conflict Description of sequence discrepancies of unknown origin
Compositional bias Region of compositional bias in the protein
Coiled coil Denotes the positions of regions of coiled coil within the protein
Chain Extent of a polypeptide chain in the mature protein
Glycosylation Covalently attached glycan group(s)
Calcium binding Denotes the position(s) of calcium binding region(s) within the protein
Binding site Binding site for any chemical group (co-enzyme, prosthetic group, etc.)
Active site Amino acid(s) directly involved in the activity of an enzyme


Protein sequence data for all described protein isoforms

Web resources

Links to related web resource(s) or database(s)