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Graphical

PML bodyNuclear bodyNucleus

Definition

The PML bodies are dynamic nuclear protein aggregates interspersed between chromatin. These punctate nuclear structures are call PML bodies because the PML gene is essential for their formation. These discrete nuclear foci, 0.2-1.0 micrometer wide, are present in most mammalian cell nuclei and typically number 1 to 30 bodies per nucleus, depending on the cell type, cell-cycle phase and differentiation stage. Recent evidence implies that, although they appear to be uniform, PML-NBs are structurally and functionally heterogeneous and are dynamic structures.

Synonyms

Kremer body
ND10
Nuclear domains-10
PML-NB
PML-nuclear body
PML oncogenic domain
Promyelocytic leukaemia nuclear body
Promyelocytic leukemia nuclear body

Category

› Cellular component

GOi

PML body [ GO:0016605 ]