Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Cellular component Nucleus speckle

    • Format
    DefinitionThe nuclear speckles are small subnuclear membraneless organelles or structures, also called the splicing factor (SF) compartments that correspond to nuclear domains located in interchromatin regions of the nucleoplasm of mammalian cells. Protein found in speckles serves as a reservoir of factors that participate in transcription and pre-mRNA processing. Speckles appear, at the immunofluorescence-microscope level, as irregular, punctuate structures, which vary in size and shape. Usually 25-50 speckles are observed per interphase mammalian nucleus. At the electronic-microscope level, they are composed of heterogeneous mixture of electro-dense particles with diameters ranging from 20-25 nm and are called interchromatin granules clusters (IGCs). Speckles are dynamic structures. Both their protein and RNA-protein components can cycle continuously between speckles and other nuclear locations depending on the transcriptional state of the cell. Structures similar to nuclear speckles have been identified in the amphibian oocyte nucleus (called B snurposomes) and in Drosophila melanogaster embryos, but not in yeast.
    Synonyms B snurposome
    Interchromatin granules clusters
    Nuclear speck
    Nuclear speckle
    SF compartments
    Splicing Factor compartments
    Splicing speckle
    Category› Cellular component
    GOinuclear speck [ GO:0016607 ]
    Graphical Nucleus speckleNucleus