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Graphical

AutophagosomeCytoplasmic vesicle

Definition

The autophagosome is a double membrane vesicle involved in the degradation of long-lived proteins, unnecessary or damaged organelles as well as other cellular constituents such as lipids or carbohydrates. Crescent-shape isolation membranes or phagophores can sequester cytoplasm and organelles giving rise to autophagosomes. The outer membrane of the autophagosomes then fuse with vacuoles and/or lysosomes and the inner membrane vesicles (termed autophagic bodies) are released into the vacuole/lysosome lumen. These vesicles are then lysed and the contents are degraded by resident hydrolases.

Synonyms

Autophagic vacuole

Category

› Cellular component

GOi

autophagosome [ GO:0005776 ]