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Keyword - Host mRNA suppression by virus (KW-1192)

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Definition

Viral protein involved in suppressing host mRNAs expression to maximize expression of viral mRNAs. Decimating cellular mRNAs eventually leads to shutoff of host proteins expression and gives virus transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response. Suppression of host mRNA can be performed by interfering with host pre-mRNA processing function (splicing or polyadenylation), by degrading mRNAs or blocking their export from the nucleus to the cytoplasm.

Category

Biological process

Graphical

Host-virus interactionHost gene expression shutoff by virusHost mRNA suppression by virusEukaryotic host gene expression shutoff by virusBiological process

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