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Keyword - Caveolin-mediated endocytosis of virus by host (KW-1166)

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Viral protein involved in virus internalization by the host cell via caveolae, which are specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the cell membrane. Caveolins form the structural backbone of caveolae. Internalization via caveolae is not a constitutive process but only occurs upon cell stimulation.Endocytic caveolae deliver their viral content to early endosomes. Caveolae represent a low capacity but highly regulated pathway. This pathway is used by viruses including HPV-31, BK virus, NDV, RSV, Coxsackie B virus, SV40, murine polyomavirus, and Echovirus 1.


  • Virion endocytosis by caveolin-coated vesicle


Biological process


caveolin-mediated endocytosis of virus by host cell [ GO:0075513 ]


Virus entry into host cellViral penetration into host cytoplasmVirus endocytosis by hostCaveolin-mediated endocytosis of virus by hostBiological process