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Keyword - Inhibition of host MHC class II molecule presentation by virus (KW-1116)

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Broader

Definition

Viral protein involved in the evasion of host adaptive immune response by inhibiting the presentation of loaded MHC class II molecules at the cell surface. MHC class II molecules are found only on a few specialized cells termed professional antigen-presenting cells (APCs). This group includes macrophages, dendritic cells and B-cells. Many viruses 'intercept' the loaded MHC class II molecules and retain them in the endoplasmic reticulum or target them to degradation in order to prevent presentation of the peptides at the cell surface.

Category

Biological process

GOi

suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II [ GO:0039505 ]

Graphical

Host-virus interactionViral immunoevasionInhibition of host adaptive immune response by virusInhibition of host MHC class II molecule presentation by virusBiological process