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Keyword - Inhibition of host interferon signaling pathway by virus (KW-1114)

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Definition

Viral protein involved in the evasion of host innate defense by inhibiting the interferon signaling pathway leading to the production of interferon-induced genes. Interferons bind to the IFN receptors (IFNAR) on the cell surface and activate Jak/Tyk kinases. These kinases phosphorylate STAT1 and STAT2 that translocate to the nucleus and induce the expression of interferon stimulated genes (ISGs). Many viruses interact with components of this pathway to prevent expression of ISGs and inhibit the host immune response.

Category

Biological process

GOi

suppression by virus of host type I interferon-mediated signaling pathway [ GO:0039502 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host interferon signaling pathway by virusBiological process