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Keyword - Inhibition of host RLR pathway by virus (KW-1113)

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Definition

Viral protein involved in the evasion of host innate defense by inhibiting the DDX58/RIG-I-like receptor (RLR) pathway leading to the triggering of interferon-mediated response. This pathway starts with the recognition of viral RNA by host proteins including DDX58/RIG-I or IFIH1. Then, the signal is transmitted through MAVS and TRAFs leading to the activation and nuclear localization of transcription factors IRF3 and IRF7 to induce IFNalpha/beta transcription and protein production. Many viruses interact with components of this pathway to inhibit production of interferons and establishment of the antiviral state.

Category

Biological process

GOi

negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [ GO:0039532 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host RLR pathway by virusBiological process