Keyword
Inhibition of host PKR by virus
| Definition | Viral protein involved in the evasion of the interferon pathway by inhibiting the interferon induced PKR/EIF2AK2 protein. During viral replication of RNA viruses, dsRNA is produced leading to the activation of the PKR/EIF2AK2 kinase. Once activated, PKR/EIF2AK2 autophosphorylates and catalyzes the phosphorylation of many substrates including the translation initiation factor EIF2S1, leading to the inhibition of the initiation of protein synthesis. Several viral proteins prevent PKR/EIF2AK2 activation by direct interaction while others target PKR/EIF2AK2 to degradation. |
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| Category |
› Biological process
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| Graphical | 
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