Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Keyword - Inhibition of host MAVS by virus (KW-1097)

Keywords navigation

Broader

Definition

Viral protein involved in the evasion of host innate defense by inhibiting the MAVS protein. During viral replication, dsRNA is produced and detected by DDX58/RIG-I or IFIH1/MDA5 that will activate MAVS to coordinate pathways leading to induction of antiviral cytokines. Several viral proteins including NS3/4A from Hepatitis C, or protease 3C from hepatitis A virus, cleave MAVS to abrogate its activity.

Category

Biological process

GOi

suppression by virus of host MAVS activity [ GO:0039545 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host MAVS by virusInhibition of host RLR pathway by virusBiological process