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Keyword - Inhibition of host MAVS by virus (KW-1097)

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Viral protein involved in the evasion of host innate defense by inhibiting the MAVS protein. During viral replication, dsRNA is produced and detected by DDX58/RIG-I or IFIH1/MDA5 that will activate MAVS to coordinate pathways leading to induction of antiviral cytokines. Several viral proteins including NS3/4A from Hepatitis C, or protease 3C from hepatitis A virus, cleave MAVS to abrogate its activity.


Biological process


suppression by virus of host MAVS activity [ GO:0039545 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host MAVS by virusInhibition of host RLR pathway by virusBiological process