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Keyword - Inhibition of host JAK1 by virus (KW-1096)

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Viral protein involved in the evasion of the type I, II and III interferon pathways by inhibiting the JAK1 protein. Upon viral infection, JAK1 is activated by the interferon-alpha/beta, -gamma, and -lambda signal transduction pathways. Several viral proteins can directly interact with JAK1 to prevent its ability to phosphorylate the downstream partners STAT1 or STAT2.


Biological process


suppression by virus of host JAK1 activity [ GO:0039576 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host JAK1 by virusInhibition of host interferon signaling pathway by virusBiological process