Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Keyword - Inhibition of host JAK1 by virus (KW-1096)

Keywords navigation

Broader

Definition

Viral protein involved in the evasion of the type I, II and III interferon pathways by inhibiting the JAK1 protein. Upon viral infection, JAK1 is activated by the interferon-alpha/beta, -gamma, and -lambda signal transduction pathways. Several viral proteins can directly interact with JAK1 to prevent its ability to phosphorylate the downstream partners STAT1 or STAT2.

Category

Biological process

GOi

suppression by virus of host JAK1 activity [ GO:0039576 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host JAK1 by virusInhibition of host interferon signaling pathway by virusBiological process