Keyword
Inhibition of host IRF3 by virus
| Definition | Viral protein involved in the evasion of host innate defense by inhibiting the interferon regulatory factor-3 (IRF3) protein. Viral infection triggers the phosphorylation and activation of IRF3. The activated IRF3 migrates to the nucleus, where it complexes with the transcription coactivator CREBBP/EP300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes. Several viral proteins directly bind to IRF3 and inhibit its transcriptional activity while others target it to the proteasome for degradation. |
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| Category |
› Biological process
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| Graphical | 
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