Keyword
Inhibition of host RIG-I by virus
| Definition | Viral protein involved in the evasion of host innate defense by inhibiting the DDX58/RIG-I protein. Upon recognition of viral RNA, the cytosolic receptor DDX58/RIG-I initiates an antiviral signaling cascade by interacting with downstream partners. Several viral proteins inhibit DDX58/RIG-I via direct interaction while others via proteolytic cleavage. |
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| Category |
› Biological process
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