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Keyword - Isopeptide bond (KW-1017)

Definition

Protein which is posttranslationally modified by the formation of an amide bond between an amino-group and a carboxyl-group at least one of which is not an alpha group. An isopeptide bond involves the side chain of one or two amino acid residues. Because there are few enzymes that hydrolyze isopeptide bonds, the formation of interchain isopeptide bonds can produce stably linked protein dimers, multimers or complexes, such as blood clots.

Category

PTM

Graphical

PTMIsopeptide bond