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Keyword - Viral immunoevasion (KW-0899)

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Definition

Viral protein involved in host immune evasion thereby optimizing viral growth and dissemination. Viral immune evasion strategies are typical of viruses which persist in their host throughout life. For example: Herpesviridae, Adenoviridae, Poxviridae and Retroviridae have developed subversions of the MHC class I antigen-presentation pathway. In order to reduce the effectiveness of cytotoxic T-lymphocytes immunity, they express proteins that either down-modulate MHC class I expression (degradation or mislocalization) or interfere with the antigen binding/presentation process (down-regulation of the expression of the transporter associated with antigen processing TAP). Some proteins of these virus families also down-regulate other molecules involved in immune recognition.

Synonyms

  • Immunoevasin
  • Viral host defense evasion
  • Viral immune evasion

Category

Biological process

GOi

evasion or tolerance by virus of host immune response [ GO:0030683 ]

Graphical

Host-virus interactionViral immunoevasionBiological process