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Keyword - Tumor antigen (KW-0825)

Definition

Protein on the surfaces of tumor cells detected by cell-mediated immunity. Different categories of tumor antigens which induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, have been identified. These are, namely, "cancer testis" (CT) antigens expressed in different tumours and normal testis, melanocyte differentiation antigens, point mutations of normal genes, self antigens that are overexpressed in malignant tissues and viral antigens.

Synonyms

  • Cancer antigen

Category

Molecular function

Graphical

Molecular functionTumor antigen