<p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.</p>
Protein involved in the synthesis of thiamine, a water-soluble vitamin member of the vitamin B complex. It occurs in cells largely as its active coenzyme form thiamine pyrophosphate, formerly called cocarboxylase. Thiamine is necessary in the diet of most vertebrates and some microorganisms. Its deficiency causes beriberi in man and polyneuritis in birds. Thiamine pyrophosphate serves as coenzyme in aldehyde-group transfers.