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Keyword - Serine protease (KW-0720)

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Proteolytic enzyme with a serine residue (Ser) in its active site. The reactivity of the serine residue is ensured by the vicinity of a histidine and an aspartate residue (catalytic triad), all three residues are required for the charge relay system to take place.


  • Serine endopeptidase
  • Serine peptidase
  • Serine proteinase


Molecular function


serine-type peptidase activity [ GO:0008236 ]


Serine proteaseProteaseMolecular functionHydrolase

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