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Keyword - Pyrogen (KW-0666)

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Broader

Definition

Protein producing fever. The major endogenous pyrogen in mammals is probably interleukin-1, which is produced by activated macrophages and acts on the hypothalamic thermoregulatory centre.

Category

Molecular function

GOi

fever generation [ GO:0001660 ]

Graphical

Molecular functionPyrogenInflammatory responseBiological process