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Keyword - Peptidoglycan synthesis (KW-0573)

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Broader

Definition

Protein involved in the synthesis of peptidoglycan which consists of a glycosaminoglycan formed by alternating residues of D-glucosamine and either muramic acid {2-amino-3-O-[(R)-1-carboxyethyl]-2-deoxy-D-glucose} or L-talosaminuronic acid (2-amino-2-deoxy-L-taluronic acid), which are usually N-acetylated or N-glycoloylated. The carboxyl group of the muramic acid is commonly substituted by a peptide containing residues of both L- and D-amino acids, whereas that of L-talosaminuronic acid is substituted by a peptide consisting of L-amino acids only. These peptide units may be cross-linked by a peptide bond, thereby giving rise to a giant macromolecule that forms the rigid cell wall (sacculus or murein sacculus). This macromolecule is known to occur as a monomolecular layer between the inner and outer membrane in Gram-negative bacteria and as a multimolecular layer, often associated covalently or non-covalently with various additional compounds (teichoic acids, neutral polysaccharides. etc.) in Gram-positive bacteria. In the archaebacteria, several organisms contain a peptidoglycan, also called pseudomurein, which differs in certain respects from those of the eubacteria.

Synonyms

  • Murein anabolism
  • Murein biosynthesis
  • Murein biosynthetic process
  • Murein formation
  • Murein synthesis
  • Peptidoglycan anabolism
  • Peptidoglycan biosynthesis
  • Peptidoglycan biosynthetic process
  • Peptidoglycan formation
  • Pseudomurein anabolism
  • Pseudomurein biosynthesis
  • Pseudomurein biosynthetic process
  • Pseudomurein formation
  • Pseudomurein synthesis

Category

Biological process

GOi

peptidoglycan biosynthetic process [ GO:0009252 ]

Graphical

Cell shapePeptidoglycan synthesisBiological process