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Keyword - Membrane attack complex (KW-0473)

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Broader

Definition

Component of the membrane attack complex which groups the complement plasma glycoproteins C5b, C6, C7, C8 and polymeric C9 on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade.

Category

Cellular component

GOi

membrane attack complex [ GO:0005579 ]

Graphical

Complement pathwayImmunityMembrane attack complexCytolysisCellular componentInnate immunityBiological process