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Keyword DNA damage

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DefinitionProtein induced by DNA damage or protein involved in the response to DNA damage. Drug- or radiation-induced injuries in DNA introduce deviations from its normal double-helical conformation. These changes include structural distortions which interfere with replication and transcription, as well as point mutations which disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. Response to DNA damage results in either repair or tolerance.
Synonyms DNA damage response
Response to DNA damage stimulus
CategoryBiological process
GOicellular response to DNA damage stimulus [ GO:0006974 ]
GraphicalBiological processDNA damage
Keywords navigation
NarrowerDNA repair