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Keyword - DNA damage (KW-0227)

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Protein induced by DNA damage or protein involved in the response to DNA damage. Drug- or radiation-induced injuries in DNA introduce deviations from its normal double-helical conformation. These changes include structural distortions which interfere with replication and transcription, as well as point mutations which disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. Response to DNA damage results in either repair or tolerance.


  • DNA damage response
  • Response to DNA damage stimulus


Biological process


cellular response to DNA damage stimulus [ GO:0006974 ]


DNA damageBiological process