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Keyword - Complement pathway (KW-0180)

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Pathway which activates the proteins of the complement system, a group of blood proteins of the globulin class involved in the lysis of foreign cells after they have been coated with antibody, and which also promote the removal of antibody-coated foreign particles by phagocytic cells. The pathway proceeds by a cascade reaction of successive binding and proteolytic cleavage of complement components. This pathway can be activated by either IgG or IgM binding to an antigen.


  • Classical complement pathway
  • Complement activation classical pathway


Biological process


complement activation, classical pathway [ GO:0006958 ]


Complement pathwayImmunityInnate immunityBiological process