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Keyword - Acetylcholine receptor inhibiting toxin (KW-0008)

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Broader

Definition

Toxin which interferes with the function of the nicotinic acetylcholine receptor (nAChR). The nAChR is a postsynaptic membrane protein that undergoes an extensive conformational change upon binding to acetylcholine, leading to opening of an ion-conducting channel across the plasma membrane. These toxins are mostly found in snake and cone snail venoms.

Synonyms

  • nAChR inhibitor
  • Nicotinic AChR inhibitor

Category

Molecular function

GOi

acetylcholine receptor inhibitor activity [ GO:0030550 ]

Graphical

NeurotoxinToxinPostsynaptic neurotoxinAcetylcholine receptor inhibiting toxinMolecular function