Viral protein involved in suppressing host mRNAs expression to maximize expression of viral mRNAs. Decimating cellular mRNAs eventually leads to shutoff of host proteins expression and gives virus transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response. Suppression of host mRNA can be performed by interfering with host pre-mRNA processing function (splicing or polyadenylation), by degrading mRNAs or blocking their export from the nucleus to the cytoplasm.

Category: Biological process · UniProtKB (20,747)

Viral protein involved in the disruption of host pre-mRNA processing. Viruses have evolved ways of interacting with the cellular RNA splicing machinery and regulate splicing of cellular pre-mRNAs as a part of the mechanism for shutting down the synthesis of host proteins. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response.

Category: Biological process · UniProtKB (20,747)

Protein involved in the processing of the primary mRNA transcript to yield a functional mRNA. This includes 5' capping, 3' cleavage and polyadenylation, as well as mRNA splicing and RNA editing.

Category: Biological process · UniProtKB (70,584)