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Cell cycle

Protein involved in the complex series of events by which the cell duplicates its contents and divides into two. The eukaryotic cell cycle can be divided in four phases termed G1 (first gap period), S (synthesis, phase during which the DNA is replicated), G2 (second gap period) and M (mitosis). The prokaryotic cell cycle typically involves a period of growth followed by DNA replication, partition of chromosomes, formation of septum and division into two similar or identical daughter cells.

Category: Biological process · UniProtKB (195,647)

G0/G1 host cell cycle checkpoint dysregulation by virus

Viral protein involved in the modulation of host cell cycle progression by dysregulating the G0/G1 transition. Some viruses benefit from keeping cells in resting state (G0), while others favor entry through G1 and subsequent cell division to replicate more efficiently.

Category: Biological process · UniProtKB (21)

G1/S host cell cycle checkpoint dysregulation by virus

Viral protein involved in the modulation of host cell cycle progression by dysregulating the G1/S transition. Some viruses benefit from an arrest in G1 to S phase transition, while others force through S phase to favor their own replication.

Category: Biological process · UniProtKB (139)

Host G2/M cell cycle arrest by virus

Viral protein involved in the modulation of host cell cycle by inhibiting the G2/M transition. A variety of viruses have been associated with G2/M arrest, including some DNA viruses, some RNA viruses and retroviruses but the mechanisms by which arrest is achieved greatly differs between those viruses.

Category: Biological process · UniProtKB (6,345)

Modulation of host cell cycle by viral cyclin-like protein

Viral protein sharing sequence homology with cellular cyclins. Most viral cyclin homologues are closely related in sequence to the cellular D-type cyclins, which are implicated in regulating the transit of cells from G1 into S and are thought to operate via the inactivation of the retinoblastoma tumour suppressor protein.

Category: Biological process · UniProtKB (4)

Modulation of host cell cycle by virus

Viral protein involved in the modulation of host cell cycle. The cell cycle can be divided into four stages: G1, S, G2 and mitosis, while cells resting are termed quiescent cells (G0). Viruses have evolved strategies to modulate cell cycle progression including stimulation of S phase entry from G1 or G0 or cell cycle arrest at G2/M for example. This regulation allows viruses to maximize their own replication.

Category: Biological process · UniProtKB (6,522)

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