Protein which contains at least one 2Fe-2S iron-sulfur cluster: 2 iron atoms complexed to 2 inorganic sulfides and 4 sulfur atoms of cysteines from the protein.

Category: Ligand · UniProtKB (13,996)

Protein, or part of a protein, whose three-dimensional structure has been resolved experimentally (for example by X-ray crystallography or NMR spectroscopy) and whose coordinates are available in the PDB database. Can also be used for theoretical models.

Category: Technical term · UniProtKB (15,301)

Protein which contains at least one 3Fe-4S iron-sulfur cluster: 3 iron atoms complexed to 4 inorganic sulfides and 3 sulfur atoms of cysteines from the protein. In a number of iron-sulfur proteins, the 4Fe-4S cluster can be reversibly converted by oxidation and loss of one iron ion to a 3Fe-4S cluster.

Category: Ligand · UniProtKB (579)

Protein which contains at least one 4Fe-4S iron-sulfur cluster: 4 iron atoms complexed to 4 inorganic sulfides and 4 sulfur atoms of cysteines from the protein. In a number of iron-sulfur proteins, the 4Fe-4S cluster can be reversibly converted by oxidation and loss of one iron ion to a 3Fe-4S cluster.

Category: Ligand · UniProtKB (46,616)

Protein involved in the synthesis of abscisic acid (ABA) (5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid). ABA is a plant hormone which play a role in many aspects of plant growth, development and cellular signaling (e.g. seed dormancy, seed maturation, vegetative growth and responses to various environmental stimuli such as stomatal closure during drought). This phytohormone can be synthesized from farnesyl diphosphate (direct C15 pathway) or from 9-cis-violaxanthine (indirect C40 pathway).

Category: Biological process · UniProtKB (18)

Protein involved in the abscisic acid (ABA) (5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid) signaling pathway (e.g. transport and signal transduction) that regulates many aspects of plant growth, development and cellular signaling (e.g. seed dormancy, seed maturation, vegetative growth and responses to various environmental stimuli such as stomatal closure during drought). This phytohormone can be synthesized from farnesyl diphosphate (direct C15 pathway) or from 9-cis-violaxanthine (indirect C40 pathway).

Category: Biological process · UniProtKB (65)

Protein involved in the synthesis of acetoin (3-hydroxy-2-butanone). Acetoin is a component of the butanediol cycle (butanediol fermentation) in microorganisms.

Category: Biological process · UniProtKB (8)

Protein involved in the degradation of acetoin (3-hydroxy-2-butanone). Acetoin is a component of the butanediol cycle (butanediol fermentation) in microorganisms.

Category: Biological process · UniProtKB (24)

Protein which is posttranslationally modified by the attachment of at least one acetyl group; generally at the N-terminus.

Category: PTM · UniProtKB (13,868)

Protein that inhibits both nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors. The nAChR is a postsynaptic membrane protein that, after binding acetylcholine, responds by an extensive change in conformation, which leads to opening of an ion-conducting channel across the plasma membrane. The mAChR is a membrane protein that acts through G proteins and mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

Category: Molecular function · UniProtKB (343)

Protein that binds to the free end of the actin filament and thereby blocks further addition of subunits.

Category: Molecular function · UniProtKB (153)

Protein which binds to actin, and thereby can modulate the properties and/or functions of the actin filament.

Category: Ligand · UniProtKB (3,463)

Protein that positively regulates either the transcription of one or more genes, or the translation of mRNA.

Category: Molecular function · UniProtKB (19,383)

Protein involved in acute phase, a response of the vertebrate body to insults, infections, immunological reactions or inflammatory processes; characterised by redness (rubor), heat (calor), swelling (tumor), pain (dolor) and sometimes loss of function.

Category: Biological process · UniProtKB (208)

Enzyme catalyzing the transfer of acyl- (RCO-) groups.

Category: Molecular function · UniProtKB (53,063)

Protein which is posttranslationally modified by the attachment of at least one ADP-ribosyl group.

Category: PTM · UniProtKB (276)

Protein which, if defective, causes age-related macular degeneration (ARMD), the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.

Category: Disease · UniProtKB (10)

Protein which, if defective, causes Aicardi-Goutieres syndrome, a genetic disorder that is phenotypically similar to in utero viral infection. The disease is characterized by severe neurological dysfunction in infancy, leading to progressive microcephaly, spasticity, dystonic posturing, profound psychomotor retardation and often death in early childhood.

Category: Disease · UniProtKB (5)

Protein encoded by the human immunodeficiency viruses HIV-1 or HIV-2, which are the cause of acquired immunodeficiency syndrome (AIDS). This disease is characterized by a severe defect of cell-mediated immunity which is often accompanied by cancers such as Kaposi's sarcoma, as well as secondary infections such as tuberculosis.

Category: Disease · UniProtKB (36,727)

Protein which, if defective, causes albinism, a genetically determined or environmentally induced absence of pigmentation in animals normally pigmented. This can lead for example to lack of pigmentation in hair, skin and eyes.

Category: Disease · UniProtKB (27)

Protein involved in the synthesis of alginate. Alginate is an exopolysaccharide in the cell walls of brown algae and in the capsular material of certain strains of Pseudomonas and Azotobacter, in which it provides a protective barrier against host immune defenses and antibiotics.

Category: Biological process · UniProtKB (72)

Protein involved in a biochemical reaction with alkaloids, a group of nitrogenous organic molecules (mostly heterocyclic) usually found in plants. Various alkaloids have toxic or medical properties, such as caffeine, morphine and nicotine.

Category: Biological process · UniProtKB (29)

Protein involved in alkylphosphonate uptake. Certain bacteria such as Escherichia coli can use alkylphosphonates as a phosphorus source.

Category: Biological process · UniProtKB (16)

Protein that stimulates the production of, and reacts with, antibodies (IgE) thus creating an allergic reaction (immediate-type hypersensitivity). Examples are pollen allergens from plants, venom allergens from insects, dust-mite allergens, and animal hair allergens.

Category: Disease · UniProtKB (460)

Enzyme whose activity is modified by the noncovalent binding of an allosteric effector at a site other than the active site. This binding mediates conformational changes, altering its catalytic or binding properties.

Category: Technical term · UniProtKB (1,149)