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Keyword Methotrexate resistance

UniProtKB (22) rdf/xml obo
DefinitionProtein that confers the ability to withstand methotrexate, an inhibitor of dehydrofolate reductase (DHFR). Methotrexate resistance occurs usually as a result of mutation or amplification of the DHFR gene.
Synonyms Resistance to methotrexate
CategoryBiological process
GOresponse to methotrexate [ GO:0031427 ]
GraphicalBiological processMethotrexate resistance