Keyword - Viral latency (KW-1251)
Viral protein expressed primarily to establish and maintain latency, the part of the viral life cycle during which a virus lies dormant (latent) within a cell. This part of the virus life cycle is called the lysogenic part in prokaryotic viruses. During latency, the viral genome can either exist as a provirus integrated in the host genome (proviral latency) or as a linear or circular plasmid in the host cell (episomal latency). The virus does not replicate, but is passively duplicated when the host divides. In eukaryotes for example, HHV-1 and HHV-3 establish episomal latency in neurons. HIV is integrated as a provirus in the genome of resting CD4-positive T cells, allowing the virus to persist for years.
- Viral lysogeny