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Alternative sequence
Last modified May 4, 2017
This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.
We describe the amino acid changes and the alternative isoform in the ‘Description’ field of each ‘Alternative sequence’ subsection. Note that several ‘Alternative sequence’ subsections may be required to completely describe a given isoform. Conversely, a particular sequence alteration may be found in more than one isoform.
Example: P04150
Each ‘Alternative sequence’ subsection has stable feature identifiers (FTIds).
Isoform sequences can be downloaded in FASTA format from our FTP download index page (choose the file: ‘Isoform sequences’).
Related keywords: Alternative splicing, Alternative initiation, Alternative promoter usage,
Ribosomal frameshifting.
Related terms: splice variant, splice isoform
Related documents
What is the canonical sequence? Are all isoforms described in one entry? How can I retrieve them?
How to retrieve a complete set of protein sequences?
How are protein sequence variety and protein diversity represented in UniProtKB?
How do I get the nucleotide sequence that corresponds to the canonical UniProtKB sequence?
What are UniProtKB’s criteria for defining a CDS as a protein?