3D-structure annotation in UniProtKB/Swiss-Prot
Last modified September 12, 2013
Manual annotation of entries with 3D-structures has high priority, for the following reasons:
- 3D-structures shed light on protein architecture and provide proof for the existence of a given protein fold.
- They show the assembly of multi-protein complexes, and the details of interactions between different proteins, such as an enzyme and its target.
- 3D-structures yield detailed information about the interactions of a protein with its ligands (substrates, ions, cofactors or regulatory molecules), and so help to elucidate enzyme mechanisms and identify active site residues.
- They help to attribute a function to so-far hypothetical proteins.
- They show post-translational modifications.
- 3D-structures pinpoint the exact position of a residue that causes a genetic disease when it is mutated.
UniProtKB/Swiss-Prot document: Index of PDB cross-references in UniProtKB/Swiss-Prot
Related keywords: 3D-structure