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UniProt release 5.5

Published July 19, 2005


Orangutan, the most represented non-human primate in UniProtKB/Swiss-Prot

With more than 500 entries, Pongo pygmaeus (Orangutan) is now the most represented non-human primate. Most of these entries are built around sequence data generated by a cDNA sequencing project launched by the German cDNA Consortium in 2003. Almost 4'000 entries submitted by the consortium are still in UniProtKB/TrEMBL. It should be noted however that some of these sequences are fragments and are thus not a priority for UniProtKB/Swiss-Prot annotation. We plan to manually annotate as many Orangutan entries as possible, starting with sequences orthologous to human ones already described in Swiss-Prot.

There are currently almost 15'500 primate entries in Swiss-Prot, 82% of which describe human proteins.

UniProtKB News

Obsolete file uniprot_trembl_varsplic.fasta.gz

All UniProtKB/TrEMBL entries with annotated alternative splicing events (KW Alternative splicing) have been moved to UniProtKB/Swiss-Prot. Thus the file uniprot_trembl_varsplic.fasta.gz became obsolete and has been removed from the ftp site.

Please note that UniProtKB/TrEMBL still includes splice isoforms, but each in an individual entry and not merged into one single entry.

Cross-references to Genew

The format of the UniProtKB cross-reference to the Human Gene Nomenclature Database Genew has changed: The term Genew has been replaced by HGNC, which stands for HUGO Gene Nomenclature Committee.


DR Genew; HGNC:12849; YWHAB.

has changed to


Changes concerning keywords

New keyword:

Deleted keyword:

  • Calcium-binding

Changes concerning the controlled vocabulary for PTMs

New terms for the feature key 'CROSSLNK':

  • Cyclopeptide (Arg-Cys) (interchain with C-...)
  • Cyclopeptide (Cys-Arg) (interchain with R-...)

New term for the feature key 'MOD_RES':

  • N6-carboxylysine