How is orthology established in UniProtKB/Swiss-Prot?

Last modified February 15, 2010

How is orthology established in UniProtKB/Swiss-Prot?

Information is combined from a variety of complementary sources to establish orthology relationships. Potential orthologs are initially identified using sequence similarity search programs such as Blast. Orthology relationships are then verified manually using a combination of resources including scientific literature, sequence analysis tools, phylogenetic and comparative genomics databases such as Ensembl Compara, and other specialised databases such as species-specific collections.