Adenylate kinase 2 - Saccharomyces cerevisiae (Baker's yeast)

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Reviewed, UniProtKB/Swiss-Prot P26364 (KAD2_YEAST)

Last modified November 25, 2008. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Adenylate kinase 2
      Short name=AK 2
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 2

Gene names

Name:	ADK2
Synonyms:	PAK3
Ordered Locus Names:	YER170W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	This small ubiquitous enzyme is essential for maintenance and cell growth.
Catalytic activity	ATP + AMP = 2 ADP.
Subcellular location	Mitochondrion.
Miscellaneous	Present with 704 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the adenylate kinase family.

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Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from direct assay. Source: SGD
Cellular component	mitochondrial inner membrane Inferred from direct assay. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro adenylate kinase activity Inferred from electronic annotation. Source: InterPro nucleoside triphosphate adenylate kinase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 225

225

Adenylate kinase 2

PRO_0000158907

Regions

Nucleotide binding

21 – 29

ATP By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P26364-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 3B192BE2535BF91F
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FASTA

225

25,194

        10         20         30         40         50         60 
MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL RQEIKSESTL 

        70         80         90        100        110        120 
GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL LDGFPRTTAQ ASALDELLKQ 

       130        140        150        160        170        180 
HDASLNLVVE LDVPESTILE RIENRYVHVP SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD 

       190        200        210        220 
DTAEVFKKRL EEYKKTNEPL KDYYKKSGIF GTVSGETSDI IFRNY

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae." Cooper A.J., Friedberg E.C. Gene 114:145-148(1992) [PubMed: 1587477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A new member of the adenylate kinase family in yeast: PAK3 is highly homologous to mammalian AK3 and is targeted to mitochondria." Schricker R., Magdolen V., Bandlow W. Mol. Gen. Genet. 233:363-371(1992) [PubMed: 1620094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DL-1.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M77757 Genomic DNA. Translation: AAA34418.1. X65126 Genomic DNA. Translation: CAA46254.1. U18922 Genomic DNA. Translation: AAB64697.1. AY558457 Genomic DNA. Translation: AAS56783.1.
PIR	S23568.
RefSeq	NP_011097.1.
3D structure databases
HSSP	HSSP built from PDB template 2AK3 based on UniProtKB P08760.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4877N.
IntAct	P26364.
Genome annotation databases
Ensembl	YER170W. Saccharomyces cerevisiae. [Contig view]
GeneID	856917.
GenomeReviews	Gene locus YER170W in contig U00092_GR.
KEGG	sce:YER170W.
NMPDR	fig\|4932.3.peg.2183.
Organism-specific databases
CYGD	YER170w.
SGD	S000000972. ADK2.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P26364.
Gene expression databases
GermOnline	YER170W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P26364.
NextBio	983371.

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Entry information

Entry name

KAD2_YEAST

Accession

Primary (citable) accession number: P26364

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	November 25, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents