TNF-receptor-associated factor 2 - Drosophila melanogaster (Fruit fly)

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Unreviewed, UniProtKB/TrEMBL Q9XYQ9 (Q9XYQ9_DROME)

Last modified November 25, 2008. Version 51. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
TNF-receptor-associated factor 2 EMBL AAD34345.1

Gene names

Name:	Traf6 FlyBase FBgn0026318
Synonyms:	TRAF2 EMBL AAD34345.1, Traf2 FlyBase FBgn0026318
ORF Names:	CG10961 FlyBase FBgn0026318

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome] EMBL AAD34345.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger. RuleBase RU000353V2

Ontologies

Keywords
Domain	Zinc-finger RuleBase RU000353V2
Ligand	Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Toll signaling pathway Traceable author statement. Source: FlyBase dorsal closure Traceable author statement. Source: FlyBase innate immune response Inferred from mutant phenotype. Source: FlyBase regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: FlyBase
Cellular component	intracellular Traceable author statement. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
wgn	Q9VWS4	1	EBI-499715,EBI-161953

Sequences

Sequence

Length

Mass (Da)

Tools

Q9XYQ9-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: D4F23B9EECD78145
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463

52,426

        10         20         30         40         50         60 
MHQHAHTHSH AHSLQHAEEK EHNSNEMTTN LSSTGRIAAS SSATPSAAAG GGASGAPTPP 

        70         80         90        100        110        120 
KSLALNQNHH YAPGSDTSGE QEEELLDSRY ECAICIDWLN EPVLTSCGHR FCRSCLTAWM 

       130        140        150        160        170        180 
QKNNQCWPMD NKRLSAEHDI FPDNYTRREI EQLKRDCPNS SLGCSVVASP IELHRHLPSC 

       190        200        210        220        230        240 
PYRRQQEPQE EKCPFAKIKC DFVGRPETNQ LEEHLKADMP HHMQLMLQAF QQTAIATWQP 

       250        260        270        280        290        300 
HKPSTSGAAV ENGHGQQQLP PPPPYANGVD EQIVQTMYQR IVVLEQRTRE QETRLENMQK 

       310        320        330        340        350        360 
QLRLARQQAP VDPRYSNGTI VWRIEQLGAL VARLRANANN QVYSHECYTS PHGYKFCARL 

       370        380        390        400        410        420 
TFSRGKPHVL SLHVHLMQSE NDYHLDWPFK GRIKLCMVHP ADATLSQHDT IMTKPEILAF 

       430        440        450        460 
HKPREAISTR GFGFLEYANI SNIIQLGFCA DDRLLIKIEI NIV

References

[1]	"A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase." Liu H., Su Y.C., Becker E., Treisman J., Skolnik E.Y. Curr. Biol. 9:101-104(1999) [PubMed: 10021364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Skolnik E.S., Liu H., Su Y.-C., Becker E., Treisman J. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
	AF119793 mRNA. Translation: AAD34345.1.
3D structure databases
HSSP	HSSP built from PDB template 1LB4 based on UniProtKB Q9Y4K3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9XYQ9.
Organism-specific databases
FlyBase	FBgn0026318. Traf6.
Gene expression databases
ArrayExpress	Q9XYQ9.
Family and domain databases
InterPro	IPR002083. MATH. IPR013322. TRAF-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Gene3D	G3DSA:2.60.210.10. TRAF-type. 1 hit. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS50144. MATH. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]

Entry information

Entry name

Q9XYQ9_DROME

Accession

Primary (citable) accession number: Q9XYQ9

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequences · References · Cross-references · Entry information