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Reviewed, UniProtKB/Swiss-Prot Q9XYP8 (GCP3_DROME)

Last modified November 25, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Gamma-tubulin complex component 3 homolog
Alternative name(s):
    Gamma-ring complex protein 91
    dGrip91
    d91p
Gene names
Name: l(1)dd4
ORF Names: CG10988
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Gamma-tubulin small complex (Gamma TuSC) is a heterotetrameric complex which contains two molecules of gamma-tubulin, and one molecule each of Dgrip84 and Dgrip91. The gamma-tubulin in this complex binds preferentially to GDP over GTP.

Subcellular location

CentrosomePotential.

Sequence similarities

Belongs to the GCP family.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9W1J91EBI-176976,EBI-161024

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 917917Gamma-tubulin complex component 3 homolog
PRO_0000078121

Experimental info

Sequence conflict791N → Y in AAD27817. Ref.1
Sequence conflict1181M → I in AAD27817. Ref.1
Sequence conflict4131L → F in AAD27817. Ref.1
Sequence conflict4791L → F in AAD27817. Ref.1
Sequence conflict5831G → A in AAD27817. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q9XYP8-1 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 6AEE88C211D256BB

FASTA917103,707
        10         20         30         40         50         60 
MSQDRIAGID VATNSTDISN IINEMIICIK GKQMPEVHEK AMDHLSKMIA ANSRVIRDSN 

        70         80         90        100        110        120 
MLTERECVQK IMKLLSARNK KEEGKTVSDH FNELYRKLTL TKCDPHMRHS LMTHLLTMTD 

       130        140        150        160        170        180 
NSDAEKAVAS EDPRTQCDNL TQILVSRLNS ISSSIASLNE MGVVNGNGVG AAAVTGAAAV 

       190        200        210        220        230        240 
TGAAAVTGAA AVTGAAASHS YDATQSSIGL RKQSLPNYLD ATKMLPESRH DIVMSAIYSF 

       250        260        270        280        290        300 
TGVQGKYLKK DVVTGRFKLD QQNIKFLTTG QAGMLLRLSE LGYYHDRVVK FSDVSTGFNA 

       310        320        330        340        350        360 
IGSMGQALIS KLKEELANFH GQVAMLHDEM QRFRQASVNG IANKGKKDSG PDAGDEMTLF 

       370        380        390        400        410        420 
KLLAWYIKPL HRMQWLTKIA DACQVKKGGD LASTVYDFLD NGNDMVNKLV EDLLTAICGP 

       430        440        450        460        470        480 
LVRMISKWIL EGGISDMHRE FFVKSIKDVG VDRLWHDKFR LRLPMLPKFV PMDMANKILM 

       490        500        510        520        530        540 
TGKSINFLRE ICEEQGMMKE RDELMKVMES SASQIFSYTP DTSWHAAVET CYQQTSKHVL 

       550        560        570        580        590        600 
DIMVGPHKLL DHLHGMRRYL LLGQGDFISI LIENMKNELE RPGLDIYAND LTSMLDSALR 

       610        620        630        640        650        660 
CTNAQYDDPD ILNHLDVIVQ RPFNGDIGWN IISLQYIVHG PLAAMLESTM PTYKVLFKPL 

       670        680        690        700        710        720 
WRMKHMEFVL SMKIWKEQMG NAKALRTMKS EIGKASHRLN LFTSEIMHFI HQMQYYVLFE 

       730        740        750        760        770        780 
VIECNWVELQ KKMQKATTLD EILEAHEKFL QTILVGCFVS NKASVEHSLE VVYENIIELE 

       790        800        810        820        830        840 
KWQSSFYKDC FKELNARKEL SKIVEKSEKK GVYGLTNKMI LQRDQEAKIF AEKMDIACRG 

       850        860        870        880        890        900 
LEVIATDYEK AVSTFLMSLN SSDDPNLQLF GTRLDFNEYY KKRDTNLSKP LTFEHMRMSN 

       910 
VFAVNSRFVI CTPSTQE

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References

« Hide 'large scale' references
[1]"Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules."
Oegema K., Wiese C., Martin O.C., Milligan R.A., Iwamatsu A., Mitchison T.J., Zheng Y.
J. Cell Biol. 144:721-733(1999) [PubMed: 10037793] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-36; 85-90; 202-227; 250-257; 277-302; 541-548; 616-626; 664-671; 799-804; 810-817 AND 863-880.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Ovary.

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Cross-references

Sequence databases

AF118380 mRNA. Translation: AAD27817.1.
AE014298 Genomic DNA. Translation: AAF48309.1.
AY069292 mRNA. Translation: AAL39437.1.
RefSeqNP_524919.2.
UniGeneDm.1749

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:19100N.
IntActQ9XYP8.

Genome annotation databases

EnsemblCG10988. Drosophila melanogaster. [Contig view]
GeneID48481.
KEGGdme:Dmel_CG10988.
NMPDRfig|7227.3.peg.17744.

Organism-specific databases

FlyBaseFBgn0001612. l(1)dd4.

Phylogenomic databases

HOGENOMQ9XYP8.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-001796-MON.

Gene expression databases

ArrayExpressQ9XYP8.
GermOnlineCG10988. Drosophila melanogaster.

Family and domain databases

InterProIPR015697. GCP3.
IPR007259. Spc97_Spc98.
[Graphical view]
PANTHERPTHR19302:SF14. GCP3. 1 hit.
PTHR19302. Spc97_Spc98. 1 hit.
PfamPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio839436.

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Entry information

Entry nameGCP3_DROME
AccessionPrimary (citable) accession number: Q9XYP8
Secondary accession number(s): Q9VY94
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 25, 2008
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents