Reviewed,
UniProtKB/Swiss-Prot Q9W596 (FUTSC_DROME)
Last modified
July 22, 2008.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Microtubule-associated protein futsch | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 5412 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch. Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching. Translation is repressed by Fmr1. |
| Subunit structure | Interacts with Fmr1. |
| Subcellular location | Cytoplasm. Cytoplasm › cytoskeleton. Note= Microtubule-associated. |
| Tissue specificity | Neuronal cells within the PNS and CNS. |
| Developmental stage | All stages. |
| Miscellaneous | 'Futsch' means 'gone' in German. |
| Sequence caution | The sequence CAA20006.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton Microtubule |
| Domain | Repeat |
| Molecular function | Developmental protein |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Cellular component | microtubule associated complex Ref.5 Inferred from direct assay. Source: UniProtKB |
| Molecular function | microtubule binding Ref.5 Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 5412 | 5412 | Microtubule-associated protein futsch | |||||
Regions | ||||||||
| Repeat | 1386 – 1419 | 34 | 1 | |||||
| Repeat | 1430 – 1456 | 27 | 2 | |||||
| Repeat | 1539 – 1566 | 28 | 3 | |||||
| Repeat | 1577 – 1603 | 27 | 4 | |||||
| Repeat | 1607 – 1635 | 29 | 5 | |||||
| Repeat | 1672 – 1699 | 28 | 6 | |||||
| Repeat | 1707 – 1735 | 29 | 7 | |||||
| Repeat | 1754 – 1782 | 29 | 8 | |||||
| Repeat | 1791 – 1819 | 29 | 9 | |||||
| Repeat | 1828 – 1856 | 29 | 10 | |||||
| Repeat | 1865 – 1893 | 29 | 11 | |||||
| Repeat | 1902 – 1930 | 29 | 12 | |||||
| Repeat | 1939 – 1967 | 29 | 13 | |||||
| Repeat | 1976 – 2004 | 29 | 14 | |||||
| Repeat | 2013 – 2041 | 29 | 15 | |||||
| Repeat | 2050 – 2078 | 29 | 16 | |||||
| Repeat | 2087 – 2115 | 29 | 17 | |||||
| Repeat | 2132 – 2160 | 29 | 18 | |||||
| Repeat | 2179 – 2209 | 31 | 19 | |||||
| Repeat | 2272 – 2308 | 37 | 20 | |||||
| Repeat | 2620 – 2643 | 24 | 21 | |||||
| Repeat | 2678 – 2704 | 27 | 22 | |||||
| Repeat | 2737 – 2763 | 27 | 23 | |||||
| Repeat | 2781 – 2809 | 29 | 24 | |||||
| Repeat | 2824 – 2850 | 27 | 25 | |||||
| Repeat | 2873 – 2904 | 32 | 26 | |||||
| Repeat | 2923 – 2951 | 29 | 27 | |||||
| Repeat | 2966 – 2992 | 27 | 28 | |||||
| Repeat | 3006 – 3034 | 29 | 29 | |||||
| Repeat | 3048 – 3075 | 28 | 30 | |||||
| Repeat | 3117 – 3141 | 25 | 31 | |||||
| Repeat | 3145 – 3173 | 29 | 32 | |||||
| Repeat | 3182 – 3210 | 29 | 33 | |||||
| Repeat | 3219 – 3247 | 29 | 34 | |||||
| Repeat | 3256 – 3284 | 29 | 35 | |||||
| Repeat | 3293 – 3321 | 29 | 36 | |||||
| Repeat | 3330 – 3358 | 29 | 37 | |||||
| Repeat | 3367 – 3395 | 29 | 38 | |||||
| Repeat | 3404 – 3432 | 29 | 39 | |||||
| Repeat | 3441 – 3469 | 29 | 40 | |||||
| Repeat | 3478 – 3506 | 29 | 41 | |||||
| Repeat | 3515 – 3543 | 29 | 42 | |||||
| Repeat | 3552 – 3580 | 29 | 43 | |||||
| Repeat | 3589 – 3617 | 29 | 44 | |||||
| Repeat | 3626 – 3654 | 29 | 45 | |||||
| Repeat | 3663 – 3691 | 29 | 46 | |||||
| Repeat | 3700 – 3728 | 29 | 47 | |||||
| Repeat | 3737 – 3765 | 29 | 48 | |||||
| Repeat | 3784 – 3811 | 28 | 49 | |||||
| Repeat | 3812 – 3838 | 27 | 50 | |||||
| Repeat | 3848 – 3875 | 28 | 51 | |||||
| Repeat | 3885 – 3912 | 28 | 52 | |||||
| Repeat | 3922 – 3949 | 28 | 53 | |||||
| Region | 1386 – 3949 | 2564 | 53 X approximate repeat | |||||
Amino acid modifications | ||||||||
| Modified residue | 2984 | 1 | Phosphoserine | |||||
| Modified residue | 2988 | 1 | Phosphoserine | |||||
| Modified residue | 2992 | 1 | Phosphoserine | |||||
Experimental info | ||||||||
| Sequence conflict | 553 – 554 | 2 | Missing in CAA20006. Ref.4 | |||||
| Sequence conflict | 649 | 1 | A → T in CAA20006. Ref.4 | |||||
| Sequence conflict | 716 | 1 | T → A in CAA20006. Ref.4 | |||||
| Sequence conflict | 1239 | 1 | G → N in CAA20006. Ref.4 | |||||
| Sequence conflict | 2229 | 1 | T → S in CAA20006. Ref.4 | |||||
| Sequence conflict | 2804 | 1 | C → S in CAA20006. Ref.4 | |||||
| Sequence conflict | 2997 | 1 | M → V in CAA20006. Ref.4 | |||||
| Sequence conflict | 3474 | 1 | E → K in CAA20006. Ref.4 | |||||
| Sequence conflict | 3488 | 1 | R → S in CAA20006. Ref.4 | |||||
| Sequence conflict | 3537 | 1 | S → Y in CAA20006. Ref.4 | |||||
| Sequence conflict | 3761 | 1 | K → E in CAA20006. Ref.4 | |||||
| Sequence conflict | 3819 | 1 | E → V in CAA20006. Ref.4 | |||||
| Sequence conflict | 4356 | 1 | T → A in CAA20006. Ref.4 | |||||
Sequences
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