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Reviewed, UniProtKB/Swiss-Prot Q9V9S7 (SYDE_DROME)

Last modified July 1, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRho GTPase-activating protein 100F
Also known as:
     RhoGAP-100F
     Synapse defective protein 1 homolog
     Protein syd-1 homolog
Gene names
Name: RhoGAP100F
ORF Names: CG1976
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.

Sequence similarities

Contains 1 C2 domain.

Contains 1 PDZ (DHR) domain.

Contains 1 Rho-GAP domain.

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Ontologies

Keywords

   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processactivation of Rho GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionRho GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 18441844Rho GTPase-activating protein 100F

Regions

Domain159 – 24486PDZ
Domain779 – 86284C2
Domain923 – 1123201Rho-GAP
Compositional bias325 – 3295Poly-Gly
Compositional bias341 – 3455Poly-Pro
Compositional bias513 – 5164Poly-Tyr
Compositional bias1377 – 1766390Ser-rich

Amino acid modifications

Modified residue6941Phosphoserine

Experimental info

Sequence conflict1159 – 11613Missing in AAM11366. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q9V9S7-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D0588015C26BB7CA

FASTA1,844195,451
        10         20         30         40         50         60 
MTVQPAEMAE NGRSVPDVTA SPGRAPPGPL PANQMPAMGN QQHHGNQQHH GNQQQHHGNQ 

        70         80         90        100        110        120 
HSNHRGQSGS LSNAAGVKDP VMLQGDFRKV SGISSEIFRQ IEAVENDHDP NTAAALEAVE 

       130        140        150        160        170        180 
RRGEMIVRVL EPRCMGSKQA VDAAHKLMNK ADARHTVQLV EIVKRPGQTL GLYIREGNGA 

       190        200        210        220        230        240 
DRTDGVFISR IALESAVYNS GCLRVGDEIL AVNLVDVTHM SLDDVVIIMS IPRRLVLAIR 

       250        260        270        280        290        300 
QRRGNRGTGS PGPPTLSRPE QKPPPVVVIK RDLRDEDLDE TDRMPRPRSS RDGREMTESR 

       310        320        330        340        350        360 
SRLGLGLNNY SPQSEQLDMY YNTRGGGGGA MGEPPNWGYK PPPPPSSVIT EQPTKAHAFA 

       370        380        390        400        410        420 
PSHAYYQNAG TLESLAEKVH AFYPGQPGGP PVGPSRRMST GTGNVGLAQQ HARFPRSGSD 

       430        440        450        460        470        480 
QHLPRVEYSD YSNSLGRHSL LRSSLKPGTT GGAPMQVGVG GTLGRYGRYD QQRAGVSKYG 

       490        500        510        520        530        540 
PPSGGAQSLT RRSRPNLDYS SDTEATIGPR PSYYYYNRPA IGSMSRGSGG AGGGVGAAST 

       550        560        570        580        590        600 
AALLAGAADL NKFNSLPRER PGTRLQGIRS RMGDRLVDEN DGNTSAPEFD VRRGRDLRQR 

       610        620        630        640        650        660 
ITASPSIFTA DEYRAWLRRA PSSSAIAEQM RMTRDMFAQP RAQRFSCSAE NIHDALRNTE 

       670        680        690        700        710        720 
SIYSSRNHIL GTGTLDRNMG LTRPISALPV RSMSSQHIGG AGSIRSPSIR RMRQLLELSA 

       730        740        750        760        770        780 
GPASPSGSIL STGGHQSPAP TPSATLPRPH RQIDINPAEF AKYKLDKPIV DIGGISGMLW 

       790        800        810        820        830        840 
IHLLAGRGLR TAPEGAAGTA TQGQTRDLYC VIECDRVHKA RTVVRSGDLQ FDWDESFELD 

       850        860        870        880        890        900 
LVGNKQLDVL VYSWDPQHRH KLCYRGAISL SSILRQSPLH QLALKVEPRG TIYIRMRHTD 

       910        920        930        940        950        960 
PLALYKRRGL PSLRAGYPTL FGADLETVVN RESKNAPGSA PVPIVLRRCV EEVERRGLDI 

       970        980        990       1000       1010       1020 
IGLYRLCGSA TKKRLLREAF ERNSRAVELT PEHVPDINVI TGVLKDYLRE LPEPLFTRCL 

      1030       1040       1050       1060       1070       1080 
FQMTVDALAV CLPDDPEGNA KLMLSILDCL PRANRATLVF LLDHLSLVVS NSERNKMSAQ 

      1090       1100       1110       1120       1130       1140 
ALATVMGPPL MLHSASAQPG ADIDHAQPIA VLKYLLQIWP QPQAQHQQMA QHMGGAAGAM 

      1150       1160       1170       1180       1190       1200 
MGGLVTAGSM SNMAGVASGN TGRRGESTGQ RGSKVSALPA DRQQLLLQQQ AQLMAAGNLL 

      1210       1220       1230       1240       1250       1260 
RSSTSVTNIL SQGHPQLSAT ANNHLYQSVV GQLAQSHRAL QQAVQQPYQL GGSVGSAIPD 

      1270       1280       1290       1300       1310       1320 
PSPLPLPGTP SPGSSSASTG SGSGSGKSTD TIKRGASPVS VKQVKIVDQP SSPYSIVMKK 

      1330       1340       1350       1360       1370       1380 
PPLQKDAPVE ITTPTTQADT ESTLGCKESN GTASRRGNVD FYDTHKTQAK SVVNEESSYS 

      1390       1400       1410       1420       1430       1440 
SKYTGSETKK IIPGNSSYTP SKANASGLSG GEDYKAMRNK SSATSSSSSS QATVLSAGST 

      1450       1460       1470       1480       1490       1500 
ATSAPTTSSD DSDDLVSYKS SASTNALLAQ SQAMTTSQLM SKYLKREPRV QFTPIKSPES 

      1510       1520       1530       1540       1550       1560 
PSPPGSGDGL PKGTYQLVTP ISGSSSKPGA TTGAISKYTT GSVESSINAN SQKLSSPSRL 

      1570       1580       1590       1600       1610       1620 
CNSKDSNSRT GTASSTTPAT SMVSTGRRLF DSLASSSSSE TETKTYIGGT TAASGAITTT 

      1630       1640       1650       1660       1670       1680 
IYTNDTKNSG SSSSKSGIGG GSGTGLGAVS GASSETRSFG STLFGSSGLG NGNGSSHNHS 

      1690       1700       1710       1720       1730       1740 
SASPSPFTTT NGNGNHNTMH LYGTLPKNGT STGAALFGGS ANSSSYHSSA SGSGAGTASS 

      1750       1760       1770       1780       1790       1800 
SGVSSMTGST NSYDFYTSTS STVSSSRPFA NGGNNYHTLG TYRAQYAATN PFLDAFDEKP 

      1810       1820       1830       1840 
GSNGGNAHGE EKLGADKGHH RAAVMAFQSS GDSKNGSDEY DDIK

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References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1023-1844.
Strain: Berkeley.
Tissue: Embryo.
[4]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, MASS SPECTROMETRY.
Tissue: Embryo.

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Cross-references

Sequence databases

AE014297 Genomic DNA. Translation: AAF57207.1.
AY095038 mRNA. Translation: AAM11366.1.
RefSeqNP_651902.1.
UniGeneDm.12850

3D structure databases

HSSPHSSP built from PDB template 1F7C based on UniProtKB Q98935.
ModBaseSearch...

Genome annotation databases

EnsemblCG1976. Drosophila melanogaster. [Contig view]
GeneID43758.
KEGGdme:Dmel_CG1976.
NMPDRfig%7C7227.3.peg.15666.

Organism-specific databases

FlyBaseFBgn0039883. RhoGAP100F.

Phylogenomic databases

HOGENOMQ9V9S7.

Gene expression databases

ArrayExpressQ9V9S7.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR001478. PDZ.
IPR000198. RhoGAP.
[Graphical view]
Gene3DG3DSA:1.10.555.10. RhoGAP. 1 hit.
PfamPF00168. C2. 1 hit.
PF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00228. PDZ. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
PROSITEPS50004. C2. False negative.
PS50106. PDZ. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProDomQ9V9S7.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameSYDE_DROME
AccessionPrimary (citable) accession number: Q9V9S7
Secondary accession number(s): Q8SWW5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 2000
Last modified: July 1, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents