Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q9V4M2 (DPLD_DROME)

Last modified July 1, 2008. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesProtein dappled
Gene names
Name: dpld
ORF Names: CG1624
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Vital for larval development. Plays a role in tumor formation.

Tissue specificity

Expressed in numerous embryonic, larval and adult tissues.

Sequence similarities

Contains 2 B box-type zinc fingers.

Contains 5 NHL repeats.

Sequence caution

AAL25460.1 sequence differs from that shown. Reason: Frameshift at position 591.

Hide | Top

Ontologies

Keywords

   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processinstar larval development Ref.5

Inferred from mutant phenotype. Source: UniProtKB

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 832832Protein dappled

Regions

Repeat537 – 58044NHL 1
Repeat584 – 62744NHL 2
Repeat631 – 67444NHL 3
Repeat680 – 72243NHL 4
Repeat727 – 77044NHL 5
Zinc finger118 – 16346B box-type 1
Zinc finger184 – 22441B box-type 2

Amino acid modifications

Modified residue1071Phosphoserine
Modified residue4701Phosphoserine
Modified residue4751Phosphoserine
Modified residue5061Phosphoserine

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9V4M2-1 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: A5672AFC3FDE1FE1

FASTA83290,573
        10         20         30         40         50         60 
MMELLSNNSV PQQMASSNAP SANNVAHSST ANGSGGGSVS SNASNSSERL LAGILESFPA 

        70         80         90        100        110        120 
WDLNVGLLPN VGQSSPPRAD FFINNFLGGL DTHGDFSIGP IGSGARSNPK MSPESSNNSS 

       130        140        150        160        170        180 
ISCGWCEVSA SIRCLECNEF MCNDCLREHR NSPLSSNHSI VSLPTPIGAS PTGGSSVNAQ 

       190        200        210        220        230        240 
TPPSGNFICD IHNEMLRYVC DYCRKLVCQC CTLHEHKEHS YASIQSFMVG SKEKLEGAIE 

       250        260        270        280        290        300 
SSQVGTRCIK SSIDKALAFI RLIERNCSEL SDNIRKAFRQ FIIAIEDRER FLLDFVEKLR 

       310        320        330        340        350        360 
QRRLAILHDQ MAGLKSALAG LSETSDMLSK VADNACNMDQ IEIAMKLTNG QRQMEQFAGI 

       370        380        390        400        410        420 
YKDLQPKQEV FAFAPPDYSL LQDIRNQGGV ILVDDKNLPI VSSSNGIVPS VSSVNAVAAA 

       430        440        450        460        470        480 
SVGVVGGVAG VVGGVGVSNG LDLAFGMNMP NNPLSVASSS VRRPLLRDNS FRIPSPIMQP 

       490        500        510        520        530        540 
RGGSACGMSS GMSSAALDWE LNGLRSSPGL HFSAPRTTQA IPGCMDLVKV RNSNALSLSF 

       550        560        570        580        590        600 
ATEGHEDGQV SRPWGLCVDK MGHVLVSDRR NNRVQVFNPD GSLKFKFGRK GVGNGEFDLP 

       610        620        630        640        650        660 
AGICVDVDNR IIVVDKDNHR VQIFTASGVF LLKFGSYGKE YGQFQYPWDV AVNSRRQIVV 

       670        680        690        700        710        720 
TDSRNHRIQQ FDSEGRFIRQ IVFDNHGQTK GIASPRGVCY TPTGNIIVSD FDNHCLYLID 

       730        740        750        760        770        780 
PDINDILSVK GHEGSGFHEF NRPSGLCCDD EGRIIVADSK NQRILVFNQN LDFMWDIEVR 

       790        800        810        820        830 
PSINPLMPPT LDEKDRTCDV AIMPDGRIVF LIELSPDSKE GSNPYKRFVH VF

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kapadia B., Kronmiller B., Li P.W., Liao G. expand/collapse author list , Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster."
Rodriguez A., Zhou Z., Tang M.L., Meller S., Chen J., Bellen H., Kimbrell D.A.
Genetics 143:929-940(1996) [PubMed: 8725239] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107; SER-470; SER-475 AND SER-506, MASS SPECTROMETRY.
Tissue: Embryo.

Hide | Top

Cross-references

Sequence databases

AE013599 Genomic DNA. Translation: AAF59246.2.
AE013599 Genomic DNA. Translation: AAM68901.1.
AY060421 mRNA. Translation: AAL25460.1. Frameshift.
BT010087 mRNA. Translation: AAQ22556.1.
BT030403 mRNA. Translation: ABO52822.1.
RefSeqNP_524772.2.
NP_724567.1.
NP_724568.1.
UniGeneDm.1824

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:21516N.

Genome annotation databases

EnsemblCG1624. Drosophila melanogaster. [Contig view]
GeneID44653.
KEGGdme:Dmel_CG1624.

Organism-specific databases

FlyBaseFBgn0015930. dpld.

Phylogenomic databases

HOGENOMQ9V4M2.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-003221-MON.
DMEL-XXX-02:DMEL-XXX-02-003222-MON.
DMEL-XXX-02:DMEL-XXX-02-003223-MON.

Gene expression databases

ArrayExpressQ9V4M2.
GermOnlineCG1624. Drosophila melanogaster.

Family and domain databases

InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR001258. NHL_repeat.
IPR013017. NHL_repeat_subgr.
IPR000315. Znf_B-box.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
PfamPF01436. NHL. 5 hits.
PF00643. zf-B_box. 2 hits.
[Graphical view]
PRINTSPR01406. BBOXZNFINGER.
SMARTSM00336. BBOX. 2 hits.
[Graphical view]
PROSITEPS51125. NHL. 5 hits.
PS50119. ZF_BBOX. 2 hits.
[Graphical view]
ProDomQ9V4M2.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Hide | Top

Entry information

Entry nameDPLD_DROME
AccessionPrimary (citable) accession number: Q9V4M2
Secondary accession number(s): A4IJ45, Q0E9G5, Q95SY8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2002
Last modified: July 1, 2008
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents