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Reviewed, UniProtKB/Swiss-Prot Q92104 (CP11B_RANCA)

Last modified September 2, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 11B, mitochondrial
    EC=1.14.15.4
Alternative name(s):
    CYPXIB
    P450C11
    Steroid 11-beta-hydroxylase
    P-450(11 beta,aldo)
Gene names
Name: CYP11B
OrganismRana catesbeiana (Bull frog)
Taxonomic identifier8400 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Rana › Aquarana

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Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis.

Catalytic activity

A steroid + reduced adrenal ferredoxin + O(2) = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processSteroidogenesis
   Cellular componentMembrane
Mitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentmitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 4545Mitochondrion Potential
Chain46 – 517472Cytochrome P450 11B, mitochondrial

Sites

Metal binding4651Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q92104-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8F94DCD66BA6370B

FASTA51759,539
        10         20         30         40         50         60 
MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS QTLPYEAIPT 

        70         80         90        100        110        120 
TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL GTHNSVNIML PQDVARLFQS 

       130        140        150        160        170        180 
EGIFPRRMTM EAWSKHRELR NHKQGVFLLN GEAWRSDRII LNKEVLSLAG VKKFLPFLDE 

       190        200        210        220        230        240 
AAADFVTFMK KRMSKNTRGS LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF 

       250        260        270        280        290        300 
ISAVETVLKT TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE 

       310        320        330        340        350        360 
RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN PSVQRELREE 

       370        380        390        400        410        420 
IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ RHLIKDIVLH NYHIPAGTLV 

       430        440        450        460        470        480 
QVGLYPMGRS PLLFQDALRY DPARWLKRED TNFKALAFGF GSRQCIGRRI AETEITLFLM 

       490        500        510 
HMLKNFQIDT VSKDDIKTVF GFILMPEKPP LLTFRPI

« Hide

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References

[1]"Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis."
Nonaka Y., Takemori H., Halder S.K., Sun T., Ohta M., Hatano O., Takakusu A., Okamoto M.
Eur. J. Biochem. 229:249-256(1995) [PubMed: 7744036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adrenal gland.

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Cross-references

Sequence databases

D10984 mRNA. Translation: BAA01756.1.
PIRS69347.

3D structure databases

HSSPHSSP built from PDB template 1SCC based on UniProtKB P00189.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ92104.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomQ92104.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP11B_RANCA
AccessionPrimary (citable) accession number: Q92104
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 2, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents