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Reviewed, UniProtKB/Swiss-Prot Q6ZMQ8 (LMTK1_HUMAN)

Last modified September 2, 2008. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein kinase LMTK1
    EC=2.7.11.1
Alternative name(s):
    Lemur tyrosine kinase 1
    Apoptosis-associated tyrosine kinase
      Short name=AATYK
    Brain apoptosis-associated tyrosine kinase
    CDK5-binding protein
    p35-binding protein
      Short name=p35BP
Gene names
Name: AATK
Synonyms: AATYK, KIAA0641, LMR1, LMTK1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1374 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in neuronal differentiation.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with CDK5.

Subcellular location

Membrane; Single-pass type I membrane proteinBy similarity. Cytoplasm. Cytoplasm › perinuclear region. Note= Predominantly perinuclear.

Tissue specificity

Expressed in brain.

Induction

Up-regulated during apoptosis.

Post-translational modification

Autophosphorylated. Phosphorylated by CDK5.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

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Ontologies

Keywords

   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZMQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZMQ8-2)

Also known as: hAATYKs-p35BP;

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.
Isoform 3 (identifier: Q6ZMQ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     468-503: Missing.
     897-915: VGTPDSLDSLDIPSSASDG → WPQREESLPRLCLLLRPRG
     916-1374: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 13741374Serine/threonine-protein kinase LMTK1

Regions

Transmembrane32 – 5221 Potential
Domain125 – 395271Protein kinase
Nucleotide binding131 – 1399ATP By similarity
Compositional bias420 – 42910Poly-Gly
Compositional bias709 – 829121Pro-rich
Compositional bias847 – 8504Poly-Ser
Compositional bias1052 – 1151100Pro-rich
Compositional bias1159 – 11635Poly-Glu

Sites

Active site2531Proton acceptor By similarity
Binding site1561ATP By similarity

Natural variations

Alternative sequence1 – 433433Missing in isoform 2.
Alternative sequence468 – 50336Missing in isoform 2 and isoform 3.
Alternative sequence897 – 91519VGTPD…SASDG → WPQREESLPRLCLLLRPRG in isoform 2 and isoform 3.
Alternative sequence916 – 1374459Missing in isoform 2 and isoform 3.
Natural variant811S → F in an ovarian mucinous carcinoma sample; somatic mutation.
Natural variant971L → V in a lung adenocarcinoma sample; somatic mutation.
Natural variant1041M → V in an ovarian mucinous carcinoma sample; somatic mutation.
Natural variant1181T → M: dbSNP rs8082016.
Natural variant7031G → C
Natural variant8151S → R
Natural variant9231S → L
Natural variant11601E → K
Natural variant11921P → S
Natural variant12661F → S
Natural variant13321A → T

Experimental info

Sequence conflict49 – 6315MLACL…GIGFK → HQVKVQGCWGRWRWQ Ref.2
Sequence conflict5111A → T in BAD18667. Ref.1
Sequence conflict5411A → T in BAD18544. Ref.1
Sequence conflict5571T → I in BAD18544. Ref.1
Sequence conflict7861A → V in AAH47378. Ref.4
Sequence conflict7901T → A in BAD18667. Ref.1
Sequence conflict10281P → R in AAH47378. Ref.4
Sequence conflict12711P → H in AAH47378. Ref.4
Sequence conflict13241P → R in AAH47378. Ref.4
Sequence conflict13601K → E in AAH47378. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: AD46BD688AF7103E

FASTA1,374144,569
        10         20         30         40         50         60 
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI 

        70         80         90        100        110        120 
GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV 

       130        140        150        160        170        180 
GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL 

       190        200        210        220        230        240 
KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG 

       250        260        270        280        290        300 
VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE 

       310        320        330        340        350        360 
LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK 

       370        380        390        400        410        420 
PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG 

       430        440        450        460        470        480 
GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK 

       490        500        510        520        530        540 
WEAGRGAEAF PATLSPGRTA RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA 

       550        560        570        580        590        600 
AGHDPDCAGC APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA 

       610        620        630        640        650        660 
RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS SGAPPLPLTG 

       670        680        690        700        710        720 
EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS AGGHAEGCPS PKQTPRASPE 

       730        740        750        760        770        780 
PGYPGEPLLG LQAASAQEPG CCPGLPHLCS AQGLAPAPCL VTPSWTETAS SGGDHPQAEP 

       790        800        810        820        830        840 
KLATEAEGTT GPRLPLPSVP SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL 

       850        860        870        880        890        900 
ASALNGSSSS PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP 

       910        920        930        940        950        960 
DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV LKEAQEGCEP 

       970        980        990       1000       1010       1020 
QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD LEAEAEATSG PEKKCGGDRA 

      1030       1040       1050       1060       1070       1080 
PGPELGLPST GQPSEQVCLR PGVSGEAQGS GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP 

      1090       1100       1110       1120       1130       1140 
PEPQGPAKVR PGPSPSCSQF FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR 

      1150       1160       1170       1180       1190       1200 
APLRLALPGL PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE 

      1210       1220       1230       1240       1250       1260 
SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR ELGEPFPGAK 

      1270       1280       1290       1300       1310       1320 
ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW DDDFPLMTAK AAFAMALDPA 

      1330       1340       1350       1360       1370 
APAPAAPTPT PAPFSRFTVS PAPTSRFSIT HVSDSDAESK RGPEAGAGGE SKEA

« Hide

Isoform 2 (hAATYKs-p35BP) [UniParc].

Checksum: 38EA067D9AA55653
Show »

44645,358
Isoform 3 [UniParc].

Checksum: B31470ED8B3E5E78
Show »

87993,226

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References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT CYS-703.
Tissue: Cerebellum and Thalamus.
[2]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-1374 (ISOFORM 1), VARIANT CYS-703.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1374 (ISOFORM 1), VARIANT SER-1266.
Tissue: Brain.
[5]"Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein."
Honma N., Asada A., Takeshita S., Enomoto M., Yamakawa E., Tsutsumi K., Saito T., Satoh T., Itoh H., Kaziro Y., Kishimoto T., Hisanaga S.
Biochem. Biophys. Res. Commun. 310:398-404(2003) [PubMed: 14521924] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORM 2), INTERACTION WITH CDK5, PHOSPHORYLATION.
[6]"A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line."
Raghunath M., Patti R., Bannerman P., Lee C.M., Baker S., Sutton L.N., Phillips P.C., Damodar Reddy C.
Brain Res. Mol. Brain Res. 77:151-162(2000) [PubMed: 10837911] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS PHE-81; VAL-97; VAL-104; CYS-703; ARG-815; LEU-923; LYS-1160; SER-1192; SER-1266 AND THR-1332.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK131395 mRNA. Translation: BAD18544.1.
AK131529 mRNA. Translation: BAD18667.1.
AB014541 mRNA. Translation: BAA31616.2.
BC047378 mRNA. Translation: AAH47378.1.
RefSeqNP_001073864.2.
UniGeneHs.514575

3D structure databases

HSSPHSSP built from PDB template 1K3A based on UniProtKB P08069.
ModBaseSearch...

PTM databases

PhosphoSiteQ6ZMQ8.

Genome annotation databases

EnsemblENSG00000181409. Homo sapiens. [Contig view]
GeneID9625.
KEGGhsa:9625.

Organism-specific databases

HGNCHGNC:21. AATK.
HPAHPA009073.
MIM605276. gene.
PharmGKBPA24370.
HUGESearch...
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ6ZMQ8.

Gene expression databases

CleanExHS_AATK.
GermOnlineENSG00000181409. Homo sapiens.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]